The German Study on Tobacco Use (DEBRA) is a bi-monthly representative, face-to-face household survey on the use of tobacco and alternative nicotine delivery systems (ANDS, such as e-cigarettes and heated tobacco products) in the German population. The study is coordinated by the Addiction Research and Clinical Epidemiology unit at the Institute of General Practice of the Heinrich-Heine-University Düsseldorf. The study has been funded by the German Ministry of Health (2019 – current) and the Ministry for Innovation, Science and Research of the German Federal State of North Rhine-Westphalia (2016 – 2019).